The neural crest is a transient population of multipotent progenitors arising at the lateral edge of the neural plate in vertebrate embryos. After delamination and migration from the neuroepithelium, these cells contribute to a diverse array of tissues including neurons, smooth muscle, craniofacial cartilage, bone cells, endocrine cells and pigment cells. Considerable progress in recent years has furthered our understanding at a molecular level of how this important group of cells is generated and how they are assigned to specific lineages. (...) Here we review a number of recent studies supporting a role for Wnt signaling in neural crest induction, differentiation, and apoptosis. We also summarize the timing of expression of a number of Wnt ligands and receptors with respect to neural crest induction. BioEssays 25:317–325, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This article discusses contemporary response to the epistemic regress problem or Agrippa's trilemma. The epistemic regress problem is considered the most crucial in the entire theory of knowledge and it is a major concern for many contemporary epistemologists. However, only two of the three alternative solutions have been developed in any detail, foundationalism and coherentism. Infinitism was not seriously considered as a solution because of the finite-mind objection. This article also provides a brief evaluation of foundationalism, emergent coherentism, and infinitism.

A distorted representation of one's own body is a diagnostic criterion and core psychopathology of both anorexia nervosa (AN) and bulimia nervosa (BN). Despite recent technical advances in research, it is still unknown whether this body image disturbance is characterized by body dissatisfaction and a low ideal weight and/or includes a distorted perception or processing of body size. In this article, we provide an update and meta-analysis of 42 articles summarizing measures and results for body size estimation (BSE) from 926 (...) individuals with AN, 536 individuals with BN and 1920 controls. We replicate findings that individuals with AN and BN overestimate their body size as compared to controls (ES= 0.63). Our meta-regression shows that metric methods (BSE by direct or indirect spatial measures) yield larger effect sizes than depictive methods (BSE by evaluating distorted pictures), and that effect sizes are larger for patients with BN than for patients with AN. To interpret these results, we suggest a revised theoretical framework for BSE that accounts for differences between depictive and metric BSE methods regarding the underlying body representations (conceptual vs. perceptual, implicit vs. explicit). We also discuss clinical implications and argue for the importance of multimethod approaches to investigate body image disturbance. (shrink)

O propósito deste artigo é mostrar como podem ser desenvolvidas explicações robustas de justificação e de certeza no interior do infinitismo. Primeiro, eu explico como a concepção infinitista de justificação epistêmica difere das concepções fundacionista e coerentista. Em segundo lugar, explico como o infinitista pode oferecer uma solução ao problema do regresso epistêmico. Em terceiro lugar, explico como o infinitismo, per se, é compatível com as teorias daqueles que sustentam 1) que o conhecimento requer certeza e que uma tal forma (...) superior de conhecimento é possível, bem como com as daqueles que rejeitam algum ou ambos os conjuntos em 1). Em outras palavras, o infinitismo nem endossa, nem rejeita o ceticismo, tomando-se essa tese como sendo aquela segundo a qual nós não possuímos conhecimento naquelas situações que nos parecem cognoscíveis. PALAVRAS-CHAVE – Certeza. Coerentismo. Fundacionismo. Infinitismo. Pirronismo. Regresso epistêmico. ABSTRACT The purpose of the paper is to show how robust accounts of justification and certainty can be developed within infinitism. First, I explain how the infinitist conception of epistemic justification differs from both the foundationalist and coherentist conceptions. Second, I explain how the infinitist can provide a solution to the epistemic regress problem. Third, I explain how infinitism, per se, is compatible with both the views of those who hold 1) that knowledge requires certainty and that such high-grade knowledge is possible as well as those who deny either or both conjuncts in 1). In other words, infinitism neither endorses nor rejects skepticism, taking that view to mean that we do not have knowledge in those areas commonly thought to be within our ken. KEY WORDS – Certainty. Coherentism. Foundationalism. Infinitism. Pyrrhonism. Epistemic regress. (shrink)

“Real knowledge,” as I use the term, is the most highly prized form of true belief sought by an epistemic agent. This paper argues that defeasible infinitism provides a good way to characterize real knowledge and it shows how real knowledge can arise from fallible justification. Then, I argue that there are two ways of interpreting Ernest Sosa's account of real knowledge as belief that is aptly formed and capable of being fully defended. On the one hand, if beliefs are (...) aptly formed only if they have a specific causal etiology, namely that they are efficiently caused fully or partially by virtuous characteristics of the epistemic agent, then Sosa's account falls prey to what I call the problem of the Hazard of Empirical Disconfirmation. The HED problem applies to all forms of causal accounts of real knowledge and is simply that as we gain more empirical knowledge about the causal origins of our true beliefs that are the most highly prized we will discover that they do not always satisfy the required efficient causal constraints. Bluntly put, having sufficiently good reasons for our beliefs might not require that the beliefs have the requisite efficient causal etiology. On the other hand, there is a way of interpreting Sosa's views that does not include an efficient causal prerequisite. That interpretation makes Sosa's account of real knowledge almost identical to defeasible infinitism but expressed in an alternate vocabulary. Such a view is not subject to the HED problem and it can solve the deep problem in epistemology, namely how to get epistemically certain knowledge from fallible justification. (shrink)

Infinitism is an ancient view in epistemology about the structure of knowledge and epistemic justification, according to which there are no foundational reasons for belief. The view has never been popular, and is often associated with skepticism, but after languishing for centuries it has recently begun a resurgence. Ad Infinitum presents new work on the topic by leading epistemologists. They shed new light on infinitism's distinctive strengths and weaknesses, and address questions, new and old, about its account of justification, reasoning, (...) epistemic responsibility, disagreement, and trust, among other important issues. The volume clarifies the relationship between infinitism and other epistemological views, such as skepticism, coherentism, foundationalism and contextualism, and it offers novel perspectives on the metaphysics, epistemology, and ethics of regresses and reasons. (shrink)

This article describes the European Corporate Sustainability Framework (ECSF). This framework addresses complex issues such as Corporate Sustainability, Corporate Responsibility and Corporate Change. It is a conceptual framework based on the tradition of the quality management approach and the concept of phase-wise development. The framework is based on several theories and models, all proven individually over several decades. These theories are the Emergent Cyclical Levels of Existence Theory (ECLET) of Professor Graves, The Four Phase Model© (Hardjono), EFQM's Business Excellence Model, (...) Kaplan and Norton's Business Balanced scorecard, the research deliverables of the project "The European Way to Excellence" and the SqEME® methodology. All these models, theories and/or studies belong to the interpretative sociology (Milwax Burell and Morgan, 1992). The aim of the ECSF is to support organizations in their implementation of Corporate Sustainability and Corporate Responsibility (CS-R) by addressing the ambiguity and complexity of these issues. (shrink)

Philosophers have sought to characterize a type of knowledge — what I call real knowledge — which is significantly different from the ordinary concept of knowledge. The concept of knowledge as true, justified belief — what I call knowledge simpliciter — failed to depict the sought after real knowledge because the necessary and jointly sufficient conditions of knowledge simpliciter can be felicitously but accidentally fulfilled. Real knowledge is knowledge simpliciter plus a set of requirements which guarantee that the truth, belief (...) and justification conditions are not accidentally conjoined. Two of those requirements have received considerable attention in recent literature by the defeasibility theorists and the causal theorists. I argue that a third requirement is needed to block the merely coincidental cosatisfaction of the belief and justification conditions and to capture our intuitions about the epistemic agent who possesses real knowledge. That condition ascribes a disposition to the real knower to believe all and only justified propositions in virtue of his/her belief that the propositions are justified. Two consequences of that requirement are discussed: (1) if S really knows that p, then S knows simpliciter that S knows simpliciter that p and (2) the iterative feature of real knowledge mentioned in (1) provides a basis for the rejection of a particularly pernicious form of scepticism. (shrink)

Infinitism, along with foundationalism and coherentism, is a logically possible solution to the epistemic regress problem. But unlike the other two views, infinitism has only been developed and defended as a plausible solution since the late 1990’s. Infinitists grant that although there is an ending point of any actual chain of cited reasons for a belief, no belief (including the last one cited) is fully justified until a reason for it is provided. In addition to differing with foundationalism about the (...) existence of so-called basic beliefs, infinitism depicts reasoning as a process through which full doxastic justification is generated, rather than as a device for merely transferring doxastic justification from one belief to another. Thus, like coherentism, infinitism attempts to account for the origin of epistemic doxastic justification without invoking self-justified beliefs whose justification is transmitted through reasoning. But infinitism parts company with coherentism by maintaining (1) that circular reasoning is unable to provide a doxastic justification for any belief and (2) that there is a linear epistemic structure of our beliefs that reflects the fact that some beliefs are epistemically prior to others. (shrink)

As the transaction cost theory of the firm was taking shape in the 1970s, another important movement in economics was emerging: a revival of the ‘Austrian’ tradition in economic theory associated with such economists as Ludwig von Mises and F. A. Hayek . As Oliver Williamson has pointed out, Austrian economics is among the diverse sources for transaction cost economics. In particular, Williamson frequently cites Hayek , particularly Hayek’s emphasis on adaptation as a key problem of economic organisation . Following (...) Williamson’s lead, a reference to Hayek’s ‘The Use of Knowledge in Society’ has become almost mandatory in discussions of economic organisation . However, there are many other potential links between Austrian and transaction cost economics that have not been explored closely and exploited.This article argues that characteristically Austrian ideas about property, entrepreneurship, economic calculation, tacit knowledge, and the temporal structure of capital have important implications for theories of economic organisation, transaction cost economics in particular. Austrian economists have not, however, devoted substantial attention to the theory of the firm, preferring to focus on business-cycle theory, welfare economics, political economy, comparative economic systems, and other areas. Until recently the theory of the firm was an almost completely neglected area in Austrian economics, but over the last decade, a small Austrian literature on the firm has emerged. While these works cover a wide variety of theoretical and applied topics, their authors share the view that Austrian insights have something to offer students of firm organisation. (shrink)

One of Israel Kirzner’s less wellknown contributions is to the theory of capital. In this paper, we link the Austrian theory of capital and the theory of economic organization. Our starting point is the key Austrian notion of capital heterogeneity which we interpret in terms of attributes. Most capital assets are multi-attribute in nature, and many attributes may not be known to entrepreneurs. This fosters a need for experimenting with capital combinations. Because there are costs of measuring attributes, this process (...) has implications for economic organization. Thus, we argue that novel implications for the understanding of ownership and the existence and boundaries of firms may be teased out of such a perspective.La théorie du capital représente une des contributions les moins connues d’Israel Kirzner. Dans cet article, nous établissons le lien entre la théorie autrichienne du capital et la théorie de l’organisation économique. Notre point de départ est la notion autrichienne fondamentale d’hétérogénéité du capital que nous interprétons en termes d’attributs. De par leur nature, la plupart des biens capitaux possèdent plusieurs attributs qui peuvent demeurer inconnus aux entrepreneurs. Ceci accroît la nécessité d’expérimenter des combinaisons capitalistiques. Etant donné les coûts qu’entraîne la mesure des attributs, ce processus a des implications quant à l’organisation économique. Ainsi, cette perspective permet de tirer de nouvelles implications pour notre compréhension de la propriété, de l’existence et de la taille des firmes. (shrink)

YouTube has been implicated in the transformation of users into extremists and conspiracy theorists. The alleged mechanism for this radicalizing process is YouTube’s recommender system, which is optimized to amplify and promote clips that users are likely to watch through to the end. YouTube optimizes for watch-through for economic reasons: people who watch a video through to the end are likely to then watch the next recommended video as well, which means that more advertisements can be served to them. This (...) is a seemingly innocuous design choice, but it has a troubling side-effect. Critics of YouTube have alleged that the recommender system tends to recommend extremist content and conspiracy theories, as such videos are especially likely to capture and keep users’ attention. To date, the problem of radicalization via the YouTube recommender system has been a matter of speculation. The current study represents the first systematic, pre-registered attempt to establish whether and to what extent the recommender system tends to promote such content. We begin by contextualizing our study in the framework of technological seduction. Next, we explain our methodology. After that, we present our results, which are consistent with the radicalization hypothesis. Finally, we discuss our findings, as well as directions for future research and recommendations for users, industry, and policy-makers. (shrink)

YouTube has been implicated in the transformation of users into extremists and conspiracy theorists. The alleged mechanism for this radicalizing process is YouTube’s recommender system, which is optimized to amplify and promote clips that users are likely to watch through to the end. YouTube optimizes for watch-through for economic reasons: people who watch a video through to the end are likely to then watch the next recommended video as well, which means that more advertisements can be served to them. This (...) is a seemingly innocuous design choice, but it has a troubling side-effect. Critics of YouTube have alleged that the recommender system tends to recommend extremist content and conspiracy theories, as such videos are especially likely to capture and keep users’ attention. To date, the problem of radicalization via the YouTube recommender system has been a matter of speculation. The current study represents the first systematic, pre-registered attempt to establish whether and to what extent the recommender system tends to promote such content. We begin by contextualizing our study in the framework of technological seduction. Next, we explain our methodology. After that, we present our results, which are consistent with the radicalization hypothesis. Finally, we discuss our findings, as well as directions for future research and recommendations for users, industry, and policy-makers. (shrink)

The 'Gettier Problem' has been central to epistemology since 1963, when Edmund Gettier presented a powerful challenge to the standard analysis of knowledge. Now twenty-six leading philosophers examine the issues that arise from Gettier's challenge, setting the agenda for future work on the central problem of epistemology.

In his 1981 article "What is 'business ethics'"? Peter Drucker maintains that the then current business ethics literature is a form of casuistry, and it provides an illegitimate argument for business apologists, while it also unjustly bashes business. I agree with W. Michael Hoffman's and Jennifer Mills Moore's criticisms of Drucker's article. However, by limiting themselves to this article, rather than considering Drucker's management works, they have missed an opportunity to benefit from his acknowledged practical wisdom. In this paper, (...) I seize the opportunity to show that Drucker takes business ethics seriously, and I develop his position on business morality. His view of business management responsibility and the related notion of a just organization is seen to be essentially Platonic. (shrink)

William Burnside was one of the three most important algebraists who were involved in the transformation of group theory from its nineteenth-century origins to a deeper twentieth-century subject. Building on work of earlier mathematicians, they were able to develop sophisticated tools for solving difficult problems. His works are of enormous historical importance; they remain also a source of inspiration and information. The works of his contemporaries, such as Klein, Frobenius, Schur, have been published as also have the works of (...) his immediate successors such as Phillip Hall. All of Burnside's papers are reproduced here, organized chronologically and with a detailed bibliography. Walter Feit has contributed a foreword, and a collection of introductory essays are included to provide a commentary on Burnside's work and set it in perspective along with a modern biography that draws on archive material. This is the first reference volume of Burnside's collected papers, enhanced by a series of critical essays on his work, and is important for group theorists and historians and philosophers of mathematics and fills the gap in this area of literature. (shrink)

In ”Skepticism,” Peter Klein distinguishes between the “Academic Skeptic” who proposes that we cannot have knowledge of a certain set of propositions and the “Pyrrhonian Skeptic” who refrains from opining about whether we can have knowledge. Klein argues that Academic Skepticism is plausibly supported by a “Closure Principle‐style” argument based on the claim that if x entails y and S has justification for x, then S has justification for y. He turns to contextualism to see if it (...) can contribute to the discussion between one who claims that we can have knowledge about some epistemically interesting class of propositions and the Academic Skeptic. He outlines the background of Pyrrhonian Skepticism, pointing out that the Pyrrhonist withholds assent concerning our knowledge‐bearing status because reason cannot provide an adequate basis for assent. He assesses three possible patterns of reasoning, and concludes that the Pyrrhonist view, that reason cannot resolve matters concerning the nonevident, is vindicated. (shrink)

Ongoing advances in paleoclimatology and paleoecology are producing an ever more detailed picture of the environments in which our species evolved. This picture is important to understanding the processes by which our large brain evolved. Our large brain and its productions—toolmaking, complex social institutions, language, art, religion—are our most striking differences from our closest living relatives. Indeed, humans are unique in the animal world for our brain size relative to body mass and in the elaboration of our cultures. We are (...) also the world’s dominant organism (Vitousek et al. 1997). We achieved our present anatomy and behavioral repertoire very recently. Fossil material attributable to our species goes back perhaps 200,000 years and artifacts that strike us as representing fully modern behavioral capacities are only about 50,000 years old (Klein 1999; McBrearty and Brooks 2000), about which time anatomically modern humans spread from Africa to Eurasia (Lahr and Foley 1994). Our ecological dominance began with the evolution of agriculture starting about 10,000 years ago. Explaining the late coming of human brains is a major evolutionary puzzle. Most important animal adaptations are old. Eyes, internal skeletons, adaptations for terrestrial life and for flight all date back hundreds of millions of years. Given that big brains and culture were such an overwhelming success for us why didn’t they evolve long ago? (shrink)

In this paper, I examine Plato’s Euthyphro phenomenologically, reading the dialogue as manifesting the posture and activity of gratitude as an essential moment of piety. This phenomenon of gratitude appears directly through Euthyphro’s own remarks and indirectly through Socrates’s interaction with Euthyphro. Other recent commentators, notably Mark McPherran, David Parry, James Brouwer, and William Mann, have noted the importance of the Euthyphro as a dialogue that offers a great deal to the discussion of piety through the shape of the relationship (...) between Socrates and Euthyphro. In building my argument, I follow Parry’s examination of the notion of therapeia or care in order to mark out my own emphasis on charis or gratitude. And I note that, when gratitude is taken as an important phenomenon in the dialogue, what also appears to the reader is the pious possibility of authentic gift-giving and mutual recognition, something Brouwer, Mann, and McPherran have also noted indirectly. Finally, in addition to its synthesis of previous scholarship around a new theme, this paper applies to the dialogue the arguments of Melanie Klein’s “Envy and Gratitude,” Martin Heidegger’s lectures entitled What Is Called Thinking, and Jacques Derrida’s Given Time. (shrink)

Political theorists have increasingly sought to place Plato in active dialogue with democracy ancient and modern by examining what S. Sara Monoson calls “Plato’s democratic entanglements.” More precisely, Monoson, J. Peter Euben, Arlene Saxonhouse, Christina Tarnopolsky, and Jill Frank approach Plato as both an immanent critic of the Athenian democracy and a searching theorist of self-governance. In this guide through the Political Theory archive, we explore “entanglement approaches” to the study of Plato, outlining their contribution to our understanding of (...) Plato’s political thought and to the discipline of political theory. (shrink)

I explore certain interconnections and commonalities among technology, corporations, and contemporary globalization in order to best understand the dangerous ethical and social consequences that accrue from them. I begin by discussing the notion of means becoming ends. Technology as means and corporate instrumental values tend to become endsin-themselves. I then suggest that technologist’s and corporate manager’s quantitative methods are ill-equipped to deal with questions of intrinsic value or ends, which are qualitative. Moreover, “development,” a key term in globalization discussions, is (...) often defined quantitatively (in economic terms) rather than qualitatively. I argue that this view is too narrow. Next, I discuss limiting autonomy as an important issue common to technology, corporations, and contemporary globalization. Material progress as a goal common to technology, corporations, and contemporary globalization is also considered. Technological mistakes and a neo-liberal, laissez-faire economy are said to be self-corrective, and this feature is used to support the notion of material progress. I argue that this has proved to be too optimistic. In the last section, I use certain contemporary leadership theorists to criticizeKenneth Galbraith’s and Peter Drucker’s views on corporate governance by technocratic specialists. I also discuss recent developments of the concept of technological assessment and related work by TU Delft researchers. (shrink)

This paper examins how the medieval distinction between proper and improper signification can give a plausible explanation of both metaphorical use and the usual transformations a language can undergo. I will show how Thomas Aquinas distinguishes between ordinary ambiguous terms and metaphors, whereas William of Ockham and Walter Burley do not leave room for this distinction. I will argue that Ockham’s conception of transfer of sense through subsequent institution of words is best thought of as an explanation of how ordinary (...) usage can contain ambiguities, whereas Burley’s conception of transfer of sense without new imposition is more plausible when it comes to explaining metaphors. If metaphorical use is lumped together with equivocation, the account of how they work cannot do full justice to either, an insight that we already find in Peter Abelard, if not in Boethius. (shrink)

Plato's paradigm for statesmanship in the Statesman, the weaving of temperate and courageous properties, provides the contemporary business ethics theorist with an aid for determining certain problems and solutions with regard to business leadership. The history of American business values manifests the destructive, and especially unethical, effects of deviating from this paradigm by over-emphasizing one or the other of the above types of qualities. However, with the aid of Plato's model for leadership in the Statesman and suggestions from Peters and (...) Waterman's In Search of Excellence, progress can be made towards constructing an adequate model for corporate leadership, especially from an ethical standpoint. (shrink)

In this paper, I examine Plato’s Euthyphro phenomenologically, reading the dialogue as manifesting the posture and activity of gratitude as an essential moment of piety. This phenomenon of gratitude appears directly through Euthyphro’s own remarks and indirectly through Socrates’s interaction with Euthyphro. Other recent commentators, notably Mark McPherran, David Parry, James Brouwer, and William Mann, have noted the importance of the Euthyphro as a dialogue that offers a great deal to the discussion of piety through the shape of the relationship (...) between Socrates and Euthyphro. In building my argument, I follow Parry’s examination of the notion of therapeia or care in order to mark out my own emphasis on charis or gratitude. And I note that, when gratitude is taken as an important phenomenon in the dialogue, what also appears to the reader is the pious possibility of authentic gift-giving and mutual recognition, something Brouwer, Mann, and McPherran have also noted indirectly. Finally, in addition to its synthesis of previous scholarship around a new theme, this paper applies to the dialogue the arguments of Melanie Klein’s “Envy and Gratitude,” Martin Heidegger’s lectures entitled What Is Called Thinking, and Jacques Derrida’s Given Time. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Psychiatric Comorbidity:More Than a Kuhnian AnomalyPeter Zachar (bio)Keywordscomorbidity, classification, epidemiology, differential diagnosis, personality disorderDr. Aragona's article in this issue of Philosophy, Psychiatry, & Psychology makes some important points regarding the relationship between comorbidity rates and the classification system currently used in psychiatry. Particularly persuasive is his claim that observed patterns of comorbidity are, in important respects, consequences of the structure of the classification system. I am not convinced, however, (...) that comorbidity is best conceptualized as an artifact of the taxonic structure of the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD). Instead, I suggest that the use of dichotomies such as true versus artifactual should be used with caution when psychiatric classification is being discussed.In contrast with the artifact hypothesis, I argue that the phenomena covered by the term "comorbidity" are real, expectable features of the psychiatric domain. They are not the phlogiston and luminiferous ether of psychiatry. I am skeptical of the notion that high comorbidity rates as a whole can be understood as Kuhnian anomalies, or that there is a crisis, or that after a period of revolutionary science a new paradigm would eliminate these 'anomalies.' In short, high rates of comorbidity in psychiatry will not simply disappear once scientists develop a better nosological paradigm. High levels of comorbidity can, however, be both lowered and provided a better, evidence-based conceptual framework.Many Conditions, One OrganIn general medicine, comorbidity conventionally refers to the simultaneous occurrence of two independent disease processes or distinct clinical entities, such as heart disease and liver cancer (Feinstein, 1970; Jablensky 2004). The presence of one disease is supposed to affect the other in such a way that the co-occurrence of the two has implications for prognosis and treatment.Comorbidity in psychiatry is a broader concept, referring to a variety of conditions that overlap in multiple ways. The different kinds of overlap are amenable to detailed empirical analysis (e. g., Klein and Riso 1993; Neale and Kendler 1995). Depressive reactions to primary disorders, attention deficit symptoms associated with mania, panic attacks in the context of severe borderline personality disorder, substance abuse disorders among psychopaths, histrionic dynamics combined [End Page 13] with narcissistic personality traits, and emergent conditions such as schizoaffective disorder are all distinct types of comorbidity. The kinds of overlapping conditions just listed are sometimes termed psychiatric comorbidity. Also important is comorbidity between psychiatric disorders and general medical conditions as is studied in behavioral medicine and health psychology. The crisis, if there is one, is a crisis of comorbidities.The heart disease and liver cancer type of comorbidity as independent organ systems being affected is ruled out a priori in psychiatric comorbidity proper. In psychiatry, "psychopathological disease processes" can all be expected to affect a single organ, namely the brain or, more likely, affect the different systems that are tightly integrated in the brain. The tight integration can make putative comorbid psychiatric disorders difficult to disentangle.It is a widely held consensus that causes, not organ systems, are what matter in comorbidity. In this tradition, Dr. Aragona claims that in general medicine shared symptoms between two diseases (such as fever and fatigue) are not a problem because the diseases are differentiated with respect to etiology; in psychiatry, however, where syndromes are differentiated by a description of symptoms only, symptomatic overlap is a problem.Is descriptive psychopathology, therefore, a root cause of the "crisis of comorbidity" and should it be abandoned in favor of etiological classification? Unfortunately, forcing psychiatric nosology to conform to an etiological paradigm is unlikely to resolve the problem of psychiatric comorbidity. As noted, the problem is one of distinguishing between the different etiological disease processes that are affecting tightly integrated systems in the brain. The brain as a whole is a multilevel, dynamic, and open system, which has an ecology (Zachar 2000). As argued by Kendler (2005) and Schaffner (2002, 2008), it has not thus far, and may never be fully possible to segregate causes and their associated psychiatric disorders into parsimonious etiological packages. In the ecology of neuroscience, causes and effects tend to merge in a continuous series of common pathways.It would be foolish... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Citizenship and Culture in Early Modern EuropePeter N. MillerCharlotte Wells, Law and Citizenship in Early Modern France (Baltimore: The Johns Hopkins University Press, 1995), xviii, 198p.Paula Findlen, Possessing Nature: Museums, Collecting, and Scientific Culture in Early Modern Italy (Berkeley, Los Angeles, and London: University of California Press, 1994), xviii, 449p.Steven Shapin, The Social History of Truth: Civility and Science in Seventeenth-Century England (Chicago and London: University of Chicago Press, (...) 1994), xxiv, 483p.Anne Goldgar, Impolite Learning: Conduct and Community in the Republic of Letters 1680–1775 (New Haven and London: Yale University Press, 1995), xv, 395p.Lawrence Klein, Shaftesbury and the Culture of Politeness: Moral Discourse and Cultural Politics in Early Eighteenth-Century England (Cambridge, U.K., 1994), xiii, 217p.Daniel Gordon, Citizens Without Sovereignty: Equality and Sociability in French Thought, 1670–1789 (Princeton: Princeton University Press, 1994), viii, 270p.Dena Goodman, The Republic of Letters: A Cultural History of the French Enlightenment (Ithaca and London: Cornell University Press, 1994), xiii, 338p.E. J. Hundert, The Enlightenment’s “Fable”: Bernard Mandeville and the Discovery of Society (Cambridge: Cambridge University Press, 1994), xii, 284p.The pre-modern political world was broken and remade in the two centuries that separate Montaigne from Jefferson. The long agony of the mixed constitution that began in the civil wars which raged in Iberia, France, the Low Countries, and England and seemed settled by the widespread adoption of the maxims of reason of state, revived at the end of the period, with revolution in Poland, Denmark, Sweden, Geneva, and, more famously, [End Page 725] British North America and France. The problem, classically, turned on the location of sovereignty, or supreme authority, in political systems designed to balance and diffuse rather than concentrate power. When budget deficits and fratricidal culture wars raised the cry of “necessity”—with the knowledge, of course, that necessity knew no law—estates and kings across Europe found themselves at daggers drawn. The claim that the ruler, who naturally was wholly committed to the common good, had therefore the ability to take emergency action was used both by those accustomed to rule and those newly attained to it by force. The pursuit of an “interest” that was identified with the nation’s effectively marginalized discussions of right and law while still serving an essentially constitutional, justificatory role in political debate. But if unchecked authority was necessary in order to meet the challenge of a world characterized by change and chance and thus had to reside somewhere, was there anything that made its exercise by one body more appropriate than another? This was the question that lay behind the late eighteenth-century repudiation of the reason of state “solution” to the problem of the mixed constitution. The answer, which clearly underpinned the establishment in fact of what had first been theorized already a century earlier, was that only consent could legitimate the exercise of sovereignty in time of necessity.1Representation, in one form or another, was the acknowledged solution to the problem formulated by Hobbes: “the name of Tyranny, signifieth nothing more, nor less, than the name of Sovereignty, be it in one, or many men, saving that they that use the former word are understood to be angry with them they call Tyrants.” But representation also acknowledged the reality behind the charged category of “citizenship”: most people in most places could not be said to live the life of the active citizen celebrated in Roman republican literature. Hence Hobbes’s attack on recourse to classical exempla in general, and the Libertas of Lucca in particular. The idea of civis as law-abiding subject was as radical a redrawing of the terms of debate as the identification of human nature with unsociability. Insofar as politics, classically, justified itself as the means for individual self-perfection, the practice of the ancient citizen could be conceived of as the practice of that best life speculated upon by philosophers. For the represented citizen, however, politics necessarily occupied a more subsidiary position. What, then, defined the best life to which he could aspire?There is no simple answer to this question, and the early modern ambivalence has persisted into our own time... (shrink)

It is a popular view thatpractical deliberation excludes foreknowledge of one's choice. Wolfgang Spohn and Isaac Levi have argued that not even a purely probabilistic self-predictionis available to thedeliberator, if one takes subjective probabilities to be conceptually linked to betting rates. It makes no sense to have a betting rate for an option, for one's willingness to bet on the option depends on the net gain from the bet, in combination with the option's antecedent utility, rather than on the offered (...) odds. And even apart from this consideration, assigning probabilities to the options among which one is choosing is futile since such probabilities could be of no possible use in choice. The paper subjects these arguments to critical examination and suggests that, appearances notwithstanding, practical deliberation need not crowd outself-prediction. (shrink)

This essay argues that Hume's political and historical thought is well read as skeptical and skeptical in a way that roots it deeply in the Hellenistic traditions of both Pyrrhonian and Academical thought. It deploys skeptical instruments to undermine political rationalism as well as theologically and metaphysically political ideologies. Hume's is politics of opinion and appearance. It labors to oppose faction and enthusiasm and generate suspension, balance, tranquility, and moderation. Because Hume advocate the use of reflectively generated but epistemically and (...) metaphysically suspensive general rules, his political thought is not intrinsically conservative. While it valorizes stability and peace, Humean politics accepts a contested and open-ended political order, one that requires continuous maintenance and revision but does not pretend to any ultimate or final progress or end. (shrink)

This comparative examination of Nietzsche and the Islamic philosopher al-Kindi emphasizes their mutual commitment to the recovery of classical Greek and Hellenistic thought and the idea of philosophy as a way of life. Affiliating both thinkers with the Stoic lineage in particular, I examine the ways in which they appropriate common themes such as fatalism, self-cultivation via spiritual exercises, and the banishing of sorrow. Focusing primarily on their respective conceptions of self and nature, I argue that the antipodal worldviews of (...) al-Kindi and Nietzsche can be understood as a bifurcation of Stoic philosophy. (shrink)

Using Martin Heidegger’s later philosophy as his springboard, Peter S. Dillard provides a radical reorientation of contemporary Christian theology. From Heidegger’s initially obscure texts concerning the holy, the gods, and the last god, Dillard extracts two possible non-metaphysical theologies: a theology of Streit and a theology of Gelassenheit. Both theologies promise to avoid metaphysical antinomies that traditionally hinder theology. After describing the strengths and weaknesses of each non-metaphysical theology, Dillard develops a Gelassenheit theology that ascribes a definite phenomenology to (...) the human encounter with divinity. This Gelassenheit theology also explains how this divinity can guide human action in concrete situations, remain deeply consonant with Christian beliefs in the Incarnation and the Trinity, and shed light on the Eucharist and Religious Vocations. Seminal ideas from Rudolf Otto and Ludwig Wittgenstein are applied at key points. Dillard concludes by encouraging others to develop an opposing Streit theology within the non-metaphysical, Heidegerrian framework he presents. (shrink)

In this book, Peter Wenz addresses the major issues and thinkers in environmental ethics. His style is accessible, even journalistic at times, featuring current facts, real controversies, and a vivid narrative, while preserving rigorous philosophical content.theories and methods are introduced, not for their own sake, but to help the reader understand and solve environmental problems.

Introduction -- Early Heidegger and scholasticism -- Heidegger's atheology of appropriation -- Heideggerian atheology and the Scotist causal argument -- Appropriation and the problem of sufficient comprehension -- Heidegger's atheology of nothingness -- Nothingness and the problem of possibility -- A positive application.

Concentrating on the views of Christopher Stone, who advocates moral pluralism, and J. Baird Callicott, who criticizes Stone’s views, I argue that the debate has been confused by a conflation of three different positions, here called minimal, moderate, and extreme moral pluralism. Minimal pluralism is uncontroversial because all known moral theories are minimally pluralistic. Extreme pluralism is defective in the ways that Callicott alleges and, moreover, is inconsistent with integrity in the moral life. However, moderate pluralism of the sort that (...) I advance in Environmental Justice is distinct from extreme pluralism and free of its defects. It is also consistent with Callicott’s version of Aldo Leopold’s land ethic, which is itself moderately pluralistic. (shrink)

This paper initiates a dialogue between classical Islamic philosophy and late modern European thought, by focusing on two peripheral, ‘heretical’ figures within these traditions: Abū Bakr Muḥammad ibn Zakariyāʾ al-Rāzī and Friedrich Nietzsche. What affiliates these thinkers across the cultural and historical chasm that separates them is their mutual fascination with, and profound indebtedness to, ancient Greek and Hellenistic philosophy. Given the specific themes, concerns and doctrines that they appropriate from this common source, I argue that al-Rāzī and Nietzsche should (...) be read as Epicureans and seen in relation to their predecessor as part of the subterranean tradition of philosophical naturalism. However, while each figure appropriates the philosophy of Epicurus, they ultimately transform it in important ways: al-Rāzī offers us a qualified “Platonic” Epicureanism, while Nietzsche forges a radicalized “Dionysian” Epicureanism. The point of such a comparative examination is twofold. First, analyzing the divergent paths of these “wayward” Epicureans sheds new light on the historical trajectory of naturalism as a philosophical stance (as well as its current prospects and limitations). Second, by initiating a dialogue between the classical Islamic and modern European philosophical traditions, we can better understand the antagonisms and shared concerns between these two horizons, as well as the ambiguities and self-questioning that occur within them. (shrink)